Melphalan flufenamide, also known as Melflufen, J-1, or Prodrug J-1, is a melphalan prodrug in which the alkylating agent melphalan is bound to flufenamide, with potential antineoplastic and anti-angiogenic activities.
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Chemical Information
Name Melphalan flufenamide
Iupac Chemical Name ethyl (S)-2-((S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanamido)-3-(4-fluorophenyl)propanoate
Synonyms J-1; J1; J 1; Prodrug J-1, Melflufen, Melphalan flufenamide
Molecular Formula C24H30Cl2FN3O3
Molecular Weight 498.4204
Smile O=C(OCC)[C@H](CC1=CC=C(F)C=C1)NC([C@H](CC2=CC=C(N(CCCl)CCCl)C=C2)N)=O
InChiKey YQZNKYXGZSVEHI-VXKWHMMOSA-N
InChi InChI=1S/C24H30Cl2FN3O3/c1-2-33-24(32)22(16-18-3-7-19(27)8-4-18)29-23(31)21(28)15-17-5-9-20(10-6-17)30(13-11-25)14-12-26/h3-10,21-22H,2,11-16,28H2,1H3,(H,29,31)/t21-,22-/m0/s1
CAS Number 380449-51-4
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Ordering Information
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Formulation Off-white solid to white solid
Purity >98%
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study