Moracin C
Moracin C is a phenolic compound isolated from Artocarpus heterophyllus. Moracin C suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Moracin C has been proven to exhibit inhibitory activities against lipoxygenase enzymes, TNF-α and interleukin-1β secretion, and proprotein convertase subtilisin/kexin type 9 expression.
For research use only. We do not sell to patients.
Chemical Information
| Name | Moracin C |
|---|---|
| Iupac Chemical Name | 1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-2-(3-methyl-2-buten-1-yl)- |
| Synonyms | Moracin C |
| Molecular Formula | C19H18O4 |
| Molecular Weight | 310.34 |
| Smile | OC1=CC(C2=CC3=CC=C(O)C=C3O2)=CC(O)=C1C/C=C(C)\C |
| InChiKey | ZTGHWUWBQNCCOH-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H18O4/c1-11(2)3-6-15-16(21)7-13(8-17(15)22)18-9-12-4-5-14(20)10-19(12)23-18/h3-5,7-10,20-22H,6H2,1-2H3 |
| CAS Number | 69120-06-5 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Parise A, De Simone BC, Marino T, Toscano M, Russo N. Quantum Mechanical Predictions of the Antioxidant Capability of Moracin C Isomers. Front Chem. 2021 Apr 21;9:666647. doi: 10.3389/fchem.2021.666647. PMID: 33968905; PMCID: PMC8097241.
2: Masagalli JN, BasavanaGowda MK, Chae HS, Choi WJ. Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells. Molecules. 2021 Mar 2;26(5):1327. doi: 10.3390/molecules26051327. PMID: 33801308; PMCID: PMC7958322.
3: You BH, BasavanaGowda MK, Lee JU, Chin YW, Choi WJ, Choi YH. Correction: Pharmacokinetic Properties of Moracin C in Mice. Planta Med. 2021 Feb 5. doi: 10.1055/a-1384-8484. Epub ahead of print. Erratum for: Planta Med. 2021 Jan 26;: PMID: 33545721.
4: You BH, BasavanaGowda MK, Lee JU, Chin YW, Choi WJ, Choi YH. Pharmacokinetic Properties of Moracin C in Mice. Planta Med. 2021 Jul;87(8):642-651. doi: 10.1055/a-1321-1519. Epub 2021 Jan 26. Erratum in: Planta Med. 2021 Feb 05;: PMID: 33498088.
5: Li X, Xie H, Zhan R, Chen D. Effect of Double Bond Position on 2-Phenyl- benzofuran Antioxidants: A Comparative Study of Moracin C and Iso-Moracin C. Molecules. 2018 Mar 24;23(4):754. doi: 10.3390/molecules23040754. PMID: 29587376; PMCID: PMC6017532.
6: Yao X, Wu D, Dong N, Ouyang P, Pu J, Hu Q, Wang J, Lu W, Huang J. Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int J Mol Sci. 2016 Jul 25;17(8):1199. doi: 10.3390/ijms17081199. PMID: 27463712; PMCID: PMC5000597.
7: Kim YJ, Sohn MJ, Kim WG. Chalcomoracin and moracin C, new inhibitors of Staphylococcus aureus enoyl-acyl carrier protein reductase from Morus alba. Biol Pharm Bull. 2012;35(5):791-5. doi: 10.1248/bpb.35.791. PMID: 22687419.
Chemical Structure
