NMD670
NMD670 is an orally bioavailable skeletal muscle-specific chloride ion channel (ClC-1) inhibitor. NMD670 showed to restore muscle function in rat models of myasthenia gravis (MG).
For research use only. We do not sell to patients.
Chemical Information
| Name | NMD670 |
|---|---|
| Iupac Chemical Name | (S)-2-(4-bromo-2-(isoxazol-3-yl)phenoxy)propanoic acid |
| Synonyms | NMD670; NMD-670; NMD 670 |
| Molecular Formula | C12H10BrNO4 |
| Molecular Weight | 312.12 |
| Smile | OC([C@H](C)OC1=CC=C(Br)C=C1C2=NOC=C2)=O |
| InChiKey | XKXLEZCOELWNMB-ZETCQYMHSA-N |
| InChi | InChI=1S/C12H10BrNO4/c1-7(12(15)16)18-11-3-2-8(13)6-9(11)10-4-5-17-14-10/h2-7H,1H3,(H,15,16)/t7-/m0/s1 |
| CAS Number | 2354321-33-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Skov M, Ruijs TQ, Grønnebæk TS, Skals M, Riisager A, Winther JB, Dybdahl KLT, Findsen A, Morgen JJ, Huus N, Broch-Lips M, Nielsen OB, de Cuba CMKE, Heuberger JAAC, de Kam ML, Tannemaat M, Verschuuren JJGM, Knutsen LJS, Kelly NM, Jensen KG, Arnold WD, Burghes AH, Olesen C, Bold J, Petersen TK, Quiroz JA, Hutchison J, Chin ER, Groeneveld GJ, Pedersen TH. The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis. Sci Transl Med. 2024 Mar 20;16(739):eadk9109. doi: 10.1126/scitranslmed.adk9109. Epub 2024 Mar 20. PMID: 38507469.
Chemical Structure
