NPS-1034 is a novel MET inhibitor, which inhibits the activated MET receptor and its constitutively active mutants. NPS-1034, inhibits various constitutively active mutant forms of MET as well as HGF-activated wild-type MET.
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Chemical Information
Name NPS-1034
Iupac Chemical Name N-(3-fluoro-4-((3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-2-(4-fluorophenyl)-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxamide
Synonyms NPS1034; NPS-1034; NPS 1034
Molecular Formula C31H23F2N5O3
Molecular Weight 551.54283
Smile FC=1C=C(C=CC1OC1=C2C(=NC=C1)NC=C2C2=CC=CC=C2)NC(=O)C=2C(N(N(C2C)C)C2=CC=C(C=C2)F)=O
InChiKey RGAZVGZUBCFHRJ-UHFFFAOYSA-N
InChi InChI=1S/C31H23F2N5O3/c1-18-27(31(40)38(37(18)2)22-11-8-20(32)9-12-22)30(39)36-21-10-13-25(24(33)16-21)41-26-14-15-34-29-28(26)23(17-35-29)19-6-4-3-5-7-19/h3-17H,1-2H3,(H,34,35)(H,36,39)
CAS Number 1221713-92-3
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Ordering Information
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Formulation off-white solid
Purity 98%
Storage 3 years -20ºCpowder
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature as non-hazardous chemical.
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study