NSC-45586
Catalog No: 20483
CAS Number: 6300-44-3
Purity: 98% Min.
NSC-45586 is a pan-PHLPP inhibitor selective for PHLPP1 and PHLPP2.
For research use only. We do not sell to patients.
Chemical Information
| Name | NSC-45586 |
|---|---|
| Iupac Chemical Name | Sodium 3-[[4-[(2,4-diamino-5-methylphenyl)diazenyl]phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylate |
| Synonyms | NSC-45586; NSC45586; NSC 45586 |
| Molecular Formula | C20H17N6NaO3 |
| Molecular Weight | 412.38 |
| Smile | O=C(C1=C/C(C=CC1=O)=N/NC2=CC=C(/N=N/C3=CC(C)=C(N)C=C3N)C=C2)[O-].[Na+] |
| InChiKey | IVOYTGYCZAPITD-MGVQZJJESA-M |
| InChi | InChI=1S/C20H18N6O3.Na/c1-11-8-18(17(22)10-16(11)21)26-24-13-4-2-12(3-5-13)23-25-14-6-7-19(27)15(9-14)20(28)29;/h2-10,23H,21-22H2,1H3,(H,28,29);/q;+1/p-1/b25-14+,26-24+; |
| CAS Number | 6300-44-3 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1. Jackson TC, Verrier JD, Drabek T, Janesko-Feldman K, Gillespie DG, Uray T, Dezfulian C, Clark RS, Bayir H, Jackson EK, Kochanek PM. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28. doi: 10.1124/jpet.113.206888. Epub 2013 Sep 10. PMID: 24023368; PMCID: PMC3807060.
Chemical Structure
