NT219
NT219 is a novel inhibitor of the insulin/igf signaling cascade (iis), mediating a long-lasting, highly efficient inhibition by a dual mechanism: it reduces the autophosphorylation of the igf1 receptor and directs the insulin receptor substrates 1 and 2 (irs 1/2) for degradation
For research use only. We do not sell to patients.
Chemical Information
| Name | NT219 |
|---|---|
| Iupac Chemical Name | (E)-3-(2-Bromo-3,4-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide |
| Synonyms | NT219; NT 219; NT-219 |
| Molecular Formula | C16H14BrNO5S |
| Molecular Weight | 412.26 |
| Smile | S=C(NCC1=CC(O)=C(O)C(O)=C1)/C=C/C2=CC=C(O)C(O)=C2Br |
| InChiKey | XDDQKKXXQHUUHJ-DUXPYHPUSA-N |
| InChi | InChI=1S/C16H14BrNO5S/c17-14-9(1-3-10(19)16(14)23)2-4-13(24)18-7-8-5-11(20)15(22)12(21)6-8/h1-6,19-23H,7H2,(H,18,24)/b4-2+ |
| CAS Number | 1198078-60-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Moll L, Ben-Gedalya T, Reuveni H, Cohen E. The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition. FASEB J. 2016 Apr;30(4):1656-69. doi: 10.1096/fj.15-281675. Epub 2015 Dec 31. PubMed PMID: 26722006.
2: El-Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E. A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell. 2014 Feb;13(1):165-74. doi: 10.1111/acel.12171. Epub 2013 Nov 22. PubMed PMID: 24261972; PubMed Central PMCID: PMC4326862.
Chemical Structure
