Neflamapimod, also known as VX-745, VRT-031745 and VD-31745, is highly potent and selective p38α inhibitor (IC50 = 10 nM).
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Chemical Information
Name | Neflamapimod |
Iupac Chemical Name | 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylsulfanyl)-6H-pyrimido[3,4-b]pyridazin-6-one |
Synonyms | VX-745; VX 745; VX745; VRT-031745, VD-31745; Neflamapimod. |
Molecular Formula | C19H9Cl2F2N3OS |
Molecular Weight | 436.26 |
Smile | ClC1=C(C(=CC=C1)Cl)C=1C(N=CN2N=C(C=CC21)SC2=C(C=C(C=C2)F)F)=O |
InChiKey | VEPKQEUBKLEPRA-UHFFFAOYSA-N |
InChi | InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H |
CAS Number | 209410-46-8 |
Related CAS | |
Ordering Information
Packaging | Price | Availability | Purity | Shipping Time |
Bulk | | Enquiry | Enquiry | Enquiry |
Formulation | off-white solid |
Purity | 98.0% |
Storage | -20 ℃ for 3 years |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature |
HS Code | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |