Nolatrexed
Catalog No: 17030908
CAS Number: 147149-76-6
Purity: 98%
Nolatrexed, also known as AG337, is a thymidylate synthase inhibitor with potential anticancer activity. A phase II study of nolatrexed in 2007 in advanced HCC patients demonstrated minimal activity and significant stomatitis. Hence, it does not warrant further study as a single agent for this disease.
For research use only. We do not sell to patients.
Chemical Information
| Name | Nolatrexed |
|---|---|
| Iupac Chemical Name | 2-Amino-6-methyl-5-(4-pyridylthio)-1H-quinazolin-4-one dihydrochloride |
| Synonyms | AG337; AG 337; AG-337; Nolatrexed HCl; Nolatrexed dihydrochloride; brand name: Thymitaq |
| Molecular Formula | C14H14Cl2N4OS |
| Molecular Weight | 357.253 |
| Smile | Cl.Cl.NC=1NC2=CC=C(C(=C2C(N1)=O)SC1=CC=NC=C1)C |
| InChiKey | PJKVJJYMWOCLIJ-UHFFFAOYSA-N |
| InChi | InChI=1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H |
| CAS Number | 147149-76-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
