O304
O-304 is a pan-activator of AMP-activated protein kinase (AMPK). It increases levels of phosphorylated AMPK (pAMPK) without reducing cellular ATP. O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients.
For research use only. We do not sell to patients.
Chemical Information
| Name | O304 |
|---|---|
| Iupac Chemical Name | 1261289-04-6 |
| Synonyms | O-304; O 304; O304; |
| Molecular Formula | C16H11Cl2N3O2S |
| Molecular Weight | 380.243 |
| Smile | O=C(NC(SN1CC2=CC=C(Cl)C=C2)=NC1=O)C3=CC=C(Cl)C=C3 |
| InChiKey | WEDWLYRQKUTOAX-UHFFFAOYSA-N |
| InChi | InChI=1S/C16H11Cl2N3O2S/c17-12-5-1-10(2-6-12)9-21-16(23)20-15(24-21)19-14(22)11-3-7-13(18)8-4-11/h1-8H,9H2,(H,19,20,22,23) |
| CAS Number | 1261289-04-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Das V, Kroin JS, Moric M, McCarthy RJ, Buvanendran A. AMP-activated protein kinase (AMPK) activator drugs reduce mechanical allodynia in a mouse model of low back pain. Reg Anesth Pain Med. 2019 Sep 20. pii: rapm-2019-100839. doi: 10.1136/rapm-2019-100839. [Epub ahead of print] PubMed PMID: 31541009.
2: Das V, Kroin JS, Moric M, McCarthy RJ, Buvanendran A. Antihyperalgesia effect of AMP-activated protein kinase (AMPK) activators in a mouse model of postoperative pain. Reg Anesth Pain Med. 2019 Jun 21. pii: rapm-2019-100651. doi: 10.1136/rapm-2019-100651. [Epub ahead of print] PubMed PMID: 31229963.
3: D'Souza N, Balyasnikova S, Tudyka V, Lord A, Shaw A, Abulafi M, Tekkis P, Brown G. Variation in landmarks for the rectum: an MRI study. Colorectal Dis. 2018 Oct;20(10):O304-O309. doi: 10.1111/codi.14398. Epub 2018 Sep 26. PubMed PMID: 30176118.
4: Steneberg P, Lindahl E, Dahl U, Lidh E, Straseviciene J, Backlund F, Kjellkvist E, Berggren E, Lundberg I, Bergqvist I, Ericsson M, Eriksson B, Linde K, Westman J, Edlund T, Edlund H. PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients. JCI Insight. 2018 Jun 21;3(12). pii: 99114. doi: 10.1172/jci.insight.99114. eCollection 2018 Jun 21. PubMed PMID: 29925691; PubMed Central PMCID: PMC6124394.
5: Riad NM, Zlotos DP, Holzgrabe U. Crystal structure of 5,11-di-hydro-pyrido[2,3-b][1,4]benzodiazepin-6-one. Acta Crystallogr E Crystallogr Commun. 2015 Apr 11;71(Pt 5):o304-5. doi: 10.1107/S2056989015006817. eCollection 2015 May 1. PubMed PMID: 25995917; PubMed Central PMCID: PMC4420050.
6: Ohno K, Fujihara T, Nagasawa A. An ortho-rhom-bic polymorph of N (1),N (4)-diphenyl-3,6-bis-(phenyl-imino)-cyclo-hexa-1,4-diene-1,4-di-amine. Acta Crystallogr Sect E Struct Rep Online. 2014 Mar 29;70(Pt 4):o495-6. doi: 10.1107/S1600536814006254. eCollection 2014 Apr 1. PubMed PMID: 24826185; PubMed Central PMCID: PMC3998558.
7: Yoon YK, Ali MA, Tan SC, Rosli MM, Razak IA. 3-{5-Eth-oxy-carbonyl-1-[3-(2-oxopyrrol-idin-1-yl)prop-yl]-1H-benzimidazol-2-yl}b enzoic acid. Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 1;69(Pt 2):o304. doi: 10.1107/S1600536813001116. Epub 2013 Jan 31. PubMed PMID: 23424569; PubMed Central PMCID: PMC3569823.
8: Yu Y. 7-Chloro-6,8-dinitro-quinazolin-4(3H)-one acetic acid monosolvate. Acta Crystallogr Sect E Struct Rep Online. 2012 Feb 1;68(Pt 2):o304. doi: 10.1107/S1600536811055735. Epub 2012 Jan 7. PubMed PMID: 22346942; PubMed Central PMCID: PMC3274997.
9: Loh WS, Fun HK, Sarveswari S, Vijayakumar V, Reddy BP. 6-Chloro-3-[5-(4-fluoro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-2-methyl-4 -phenyl-quinoline. Acta Crystallogr Sect E Struct Rep Online. 2010 Jan 9;66(Pt 2):o304. doi: 10.1107/S1600536810000218. PubMed PMID: 21579737; PubMed Central PMCID: PMC2979872.
10: Zhang M, Yuan XY, Liu XM. 2,2-Dimethyl-5-triphenyl-methyl-1,3-dioxane. Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 14;65(Pt 2):o304. doi: 10.1107/S1600536809000294. PubMed PMID: 21581913; PubMed Central PMCID: PMC2968387.
11: Portalone G, Colapietro M. Nicotinohydrazide. Acta Crystallogr Sect E Struct Rep Online. 2007 Dec 18;64(Pt 1):o304. doi: 10.1107/S1600536807066561. PubMed PMID: 21200868; PubMed Central PMCID: PMC2915352.
12: Batsanov AS, Goeta AE, Howard JA, Soto B, Au-Alvarez O. 2-(4-Chloroanilino)- and 2-(4-methoxyanilino)-1,2-diphenylethanone. Acta Crystallogr C. 2006 May;62(Pt 5):o304-6. Epub 2006 Apr 29. PubMed PMID: 16679611.
Chemical Structure
