Oxolinic acid is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.Oxolinic acid, a quinolone antibacterial agent, inhibits reversibly the ATP-dependent replicative DNA synthesis in permeable cell systems as well as in cellophane disk lysates[4]. It also inhibits bacterial DNA gyrase but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 g/ml
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Name | Oxolinic acid |
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Iupac Chemical Name | Oxolinic acid |
Synonyms | Urinox, NSC 110364 |
Molecular Formula | C13H11NO5 |
Molecular Weight | 261.23 |
Smile | CCN1C=C(C(=O)C=2C1=CC1=C(C2)OCO1)C(=O)O |
InChiKey | KYGZCKSPAKDVKC-UHFFFAOYSA-N |
InChi | InChI=1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17) |
CAS Number | 14698-29-4 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Formulation | crystalline solid |
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Purity | 98% |
Storage | 3 years -20ºCpowder |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
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Cell study | |
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Clinical study |