Oxyresveratrol, a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.
Oxyresveratrol has been reported to inhibit -amyloid-induced neurotoxicity in cultured cortical neurons and in vitro activity of -secretase, an enzyme vital for the production of the A protein. And it can also prevent neurotoxicity and DNA damage through its antioxidant properties in cultured neuronal cells. It shows modest inhibitory activity against H5N1 neuraminidase (an enzyme found in avian influenza virus), but strong inhibition against -glucosidase, an enzyme responsible for the breaking down of starch and polysaccharides into glucose in the intestine. Oxyresveratrol is an effective radical scavenger. Oxyresveratrol protects hepatocytes against oxidative stress, mitochondrial damage, and resultant cell death. It induces activation of an antioxidant transcription factor, Nrf2, mediated through ERK phosphorylation.
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