PH-797804 is a potent and selectiove inhibitor of p38 mitogen-activated protein (MAP) kinase. PH-797804 reduces tumor growth of the three PDXs, which correlates with impaired colon tumor cell proliferation and survival.
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Chemical Information
Name PH-797804
Iupac Chemical Name 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide
Synonyms PH-797804; PH 797804; PH797804
Molecular Formula C22H19BrF2N2O3
Molecular Weight 477.29867
Smile FC1=C(COC2=C(C(N(C(=C2)C)C=2C=C(C(=O)NC)C=CC2C)=O)Br)C=CC(=C1)F
InChiKey KCAJXIDMCNPGHZ-UHFFFAOYSA-N
InChi InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)
CAS Number 586379-66-0
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Ordering Information
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Formulation off-white solid
Purity 98%
Storage 3 years -20ºCpowder
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature as non-hazardous chemical.
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study