PQR620
Catalog No: 611821
CAS Number: 1927857-56-4
Purity: 98%
PRQ620 is a highly potent and selective mTORC1/2 inhibitor, shows anti-tumor effects in vitro and in vivo.
PQR620 demonstrated its potency to prevent cancer cell growth in an NTRC 44 cancer cell line panel, resulting in a 10log(IC50) of 2.86 (nM), induced a >1000-fold selectivity towards mTOR over PI3K in enzymatic binding assays. showed excellent selectivity over a wide panel of kinases, as well as excellent selectivity versus unrelated receptor enzymes and ion channels.PQR620 result in good oral bioavailability and excellent brain penetration.
For research use only. We do not sell to patients.
Chemical Information
| Name | PQR620 |
|---|---|
| Iupac Chemical Name | PQR620 |
| Synonyms | PQR-620; PQR 620 |
| Molecular Formula | C21H25F2N7O2 |
| Molecular Weight | 445.47 |
| Smile | C[Si](C)(C)CSCCl |
| InChiKey | IKWIERSJEROYFH-UHFFFAOYSA-N |
| InChi | InChI=1S/C5H13ClSSi/c1-8(2,3)5-7-4-6/h4-5H2,1-3H3 |
| CAS Number | 1927857-56-4 |
| MDL | MFCD17013410 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
