PRN-1371 is a covalent, irreversible, highly selective FGFR1, 2, 3 and 4 inhibitor. PRN1371 inhibits all four FGFR isoforms and blocks aberrant FGFR kinase signaling.
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Chemical Information
Name PRN-1371
Synonyms PRN-1371; PRN1371; PRN 1371.
Molecular Formula C26H30Cl2N6O4
Molecular Weight 561.464
Smile CNC1=NC=C2C(N(CCCN3CCN(C(C=C)=O)CC3)C(C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)=C2)=O)=N1
InChiKey PUIXMSRTTHLNKI-UHFFFAOYSA-N
InChi InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)
CAS Number 1802929-43-6
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Ordering Information
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Formulation o
Purity >98%
Storage 3 years -20ºCpowder
Solubility Soluble in DMSO, not in water
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study