Phylloflavan
Phylloflavan is an antileishmanial agent with an intracellular EC50 of 3.2 nM in RAW 264.7 cells. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblast cells (38 U/mL).
For research use only. We do not sell to patients.
Chemical Information
| Name | Phylloflavan |
|---|---|
| Iupac Chemical Name | (2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl (S)-5-(3,4-dihydroxyphenyl)-3-hydroxypentanoate |
| Synonyms | Phylloflavan; 9T7A4KA6YL; UNII-9T7A4KA6YL |
| Molecular Formula | C26H26O10 |
| Molecular Weight | 498.48 |
| Smile | O=C(C[C@@H](O)CCC1=CC(O)=C(O)C=C1)O[C@H]2CC3=C(O)C=C(O)C=C3O[C@@H]2C4=CC(O)=C(O)C=C4 |
| InChiKey | FKDRTLFRRHQTGU-TYFWRAIDSA-N |
| InChi | InChI=1S/C26H26O10/c27-15(4-1-13-2-5-18(29)21(32)7-13)11-25(34)35-24-12-17-20(31)9-16(28)10-23(17)36-26(24)14-3-6-19(30)22(33)8-14/h2-3,5-10,15,24,26-33H,1,4,11-12H2/t15-,24-,26+/m0/s1 |
| CAS Number | 98570-83-3 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Aloufi BH, Snoussi M, Sulieman AME. Antiviral Efficacy of Selected Natural
Phytochemicals against SARS-CoV-2 Spike Glycoprotein Using Structure-Based Drug
Designing. Molecules. 2022 Apr 8;27(8):2401. doi: 10.3390/molecules27082401.
PMID: 35458599; PMCID: PMC9025634.
2: Kolodziej H, Kayser O, Kiderlen AF, Ito H, Hatano T, Yoshida T, Foo LY.
Proanthocyanidins and related compounds: antileishmanial activity and modulatory
effects on nitric oxide and tumor necrosis factor-alpha-release in the murine
macrophage-like cell line RAW 264.7. Biol Pharm Bull. 2001 Sep;24(9):1016-21.
doi: 10.1248/bpb.24.1016. PMID: 11558561.
Chemical Structure
