RG3039 is a potent DcpS inhibitor, which can improve motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models.
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Chemical Information
Name RG3039
Iupac Chemical Name 5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine
Synonyms RG 3039; RG-3039; PF-06687859; PF 06687859; PF06687859
Molecular Formula C21H23Cl2N5O
Molecular Weight 432.35
Smile NC1=NC(N)=C2C(OCC3CCN(CC4=C(Cl)C=CC=C4Cl)CC3)=CC=CC2=N1.[H]Cl.[H]Cl
InChiKey SRIYKPCSVUEGET-UHFFFAOYSA-N
InChi InChI=1S/C21H23Cl2N5O.2ClH/c22-15-3-1-4-16(23)14(15)11-28-9-7-13(8-10-28)12-29-18-6-2-5-17-19(18)20(24)27-21(25)26-17;;/h1-6,13H,7-12H2,(H4,24,25,26,27);2*1H
CAS Number 1005504-62-0
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Ordering Information
Packaging Price Availability Purity Shipping Time
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Formulation Solid powder
Purity 97%
Storage -20 ºC for 3 years
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study