RGT-018
Catalog No: 24148
CAS Number: 2794934-49-7
Purity: 98% Min.
RGT-018 is a potent and orally active SOS1 inhibitor with anti-tumor effects.
For research use only. We do not sell to patients.
Chemical Information
| Name | RGT-018 |
|---|---|
| Iupac Chemical Name | (R)-5-(4-((1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-2-methyl-6-morpholino-7-oxo-6,7-dihydropyrido[4,3-d]pyrimidin-8-yl)picolinonitrile |
| Synonyms | RGT-018; RGT 018; RGT018 |
| Molecular Formula | C27H24F3N7O2 |
| Molecular Weight | 535.52 |
| Smile | O=C1C(C2=CN=C(C#N)C=C2)=C3C(C(N[C@@H](C4=C(C(C(F)F)=CC=C4)F)C)=NC(C)=N3)=CN1N5CCOCC5 |
| InChiKey | HRMKBFIINYRRDO-OAHLLOKOSA-N |
| InChi | InChI=1S/C27H24F3N7O2/c1-15(19-4-3-5-20(23(19)28)25(29)30)33-26-21-14-37(36-8-10-39-11-9-36)27(38)22(24(21)34-16(2)35-26)17-6-7-18(12-31)32-13-17/h3-7,13-15,25H,8-11H2,1-2H3,(H,33,34,35)/t15-/m1/s1 |
| CAS Number | 2794934-49-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Xiao F, Wang K, Wang X, Li H, Hu Z, Ren X, Huang W, Feng T, Yao L, Lin J, Li C, Zhang Z, Mei L, Zhu X, Zhong W, Xie Z. Discovery of RGT-018: a Potent, Selective and Orally Bioavailable SOS1 Inhibitor for KRAS-driven Cancers. Mol Cancer Ther. 2024 Aug 1. doi: 10.1158/1535-7163.MCT-24-0049. Epub ahead of print. PMID: 39087485.
Chemical Structure
