RMC-4998
Catalog No: 20666
CAS Number: 2642037-07-6
Purity: 98% Min.
RMC-4998 is a tri-complex inhibitor and KRASG12C inhibitor. RMC-4998 targets the active or GTP-bound state of KRASG12C. Disruption of effector binding by RMC-4998 inhibited downstream ERK signaling in KRASG12C mutant cancer cell models with an IC50 ranging between 1 and 10 nM. RMC-4998 had median IC50 of 0.28 nM and selectivity index of 1450. Of note, both the potency and the selectivity index of RMC-4998 and RMC-6291 were greater than those of adagrasib.
For research use only. We do not sell to patients.
Chemical Information
| Name | RMC-4998 |
|---|---|
| Iupac Chemical Name | (2S)-2-((S)-7-(4-(dimethylamino)-4-methylpent-2-ynoyl)-1-oxo-2,7-diazaspiro[4.4]nonan-2-yl)-N-((63S,4S)-11-ethyl-12-(2-((S)-1-methoxyethyl)pyridin-3-yl)-10,10-dimethyl-5,7-dioxo-61,62,63,64,65,66-hexahydro-11H-8-oxa-1(5,3)-indola-6(1,3)-pyridazina-2(1,3)-benzenacycloundecaphane-4-yl)-3-methylbutanamide |
| Synonyms | RMC-4998; RMC 4998; RMC4998; |
| Molecular Formula | C57H74N8O7 |
| Molecular Weight | 983.268 |
| Smile | O=C(N1CCC[C@@H](C2=O)N1)[C@@H](NC([C@H](C(C)C)N3C([C@@]4(CCN(C(C#CC(C)(C)N(C)C)=O)C4)CC3)=O)=O)CC5=CC(C6=CC(C(CC(C)(C)CO2)=[C@@]([C@@]7=C([C@H](C)OC)N=CC=C7)N8CC)=C8C=C6)=CC=C5 |
| InChiKey | |
| InChi | |
| CAS Number | 2642037-07-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
