RO5045337
Catalog No: 16071112
CAS Number: 939981-39-2
Purity: 98% by HPLC
RO5045337, also known as R7112, RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent.
For research use only. We do not sell to patients.
Chemical Information
| Name | RO5045337 |
|---|---|
| Iupac Chemical Name | ((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl)(4-(3-(methylsulfonyl)propyl)piperazin-1-yl)methanone |
| Synonyms | R7112 RG7112 |
| Molecular Formula | C38H48Cl2N4O4S |
| Molecular Weight | 727.78 |
| Smile | C(C)(C)(C)C1=CC(=C(C=C1)C=1N([C@]([C@](N1)(C)C1=CC=C(C=C1)Cl)(C)C1=CC=C(C=C1)Cl)C(=O)N1CCN(CC1)CCCS(=O)(=O)C)OCC |
| InChiKey | QBGKPEROWUKSBK-QPPIDDCLSA-N |
| InChi | InChI=1S/C38H48Cl2N4O4S/c1-8-48-33-26-29(36(2,3)4)14-19-32(33)34-41-37(5,27-10-15-30(39)16-11-27)38(6,28-12-17-31(40)18-13-28)44(34)35(45)43-23-21-42(22-24-43)20-9-25-49(7,46)47/h10-19,26H,8-9,20-25H2,1-7H3/t37-,38+/m0/s1 |
| CAS Number | 939981-39-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
