RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
RU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.
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Name | RU-SKI 43 |
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Iupac Chemical Name | RU-SKI 43 |
Synonyms | RU-SKI43; Hhat Inhibitor |
Molecular Formula | C22H30N2O2S |
Molecular Weight | 386.55 |
InChiKey | |
InChi | |
CAS Number | 1043797-53-0 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | crystalline solid |
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Purity | 98% |
Storage | 3 years -20ºCpowder |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
HS Code |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |