Ranirestat, also known as AS-3201; SX-3201, is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy by Dainippon Sumitomo Pharma and PharmaKyorin.
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Chemical Information
Name Ranirestat
Iupac Chemical Name (3R)-2��-[(4-Bromo-2-fluorophenyl)methyl]spiro[pyrrolidine-3,4��(1��H)-pyrrolo[1,2-a]pyrazine]-1��,2,3��,5(2��H)-tetrone
Synonyms Ranirestat;AS-3201;AS3201;AS 3201;SX-3201;SX 3201;SX3201
Molecular Formula C17H11BrFN3O4
Molecular Weight 420.19
Smile c1cc2n(c1)[C@@]3(CC(=O)NC3=O)C(=O)N(C2=O)Cc4ccc(cc4F)Br
InChiKey QCVNMNYRNIMDKV-QGZVFWFLSA-N
InChi InChI=1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1
CAS Number 147254-64-6
MDL MFCD00920915
Related CAS
Ordering Information
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Formulation off-white solid
Purity 98.0%
Storage -20 ºC for 3 years
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study