Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3.
For research use only. We do not sell to patients.
Name | Rigosertib sodium |
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Iupac Chemical Name | Sodium (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate |
Synonyms | ON01910; ON 01910; ON-01910; Rigosertib sodium |
Molecular Formula | C21H24NNaO8S |
Molecular Weight | 473.47 |
Smile | COc1ccc(cc1NCC(=O)[O-])CS(=O)(=O)/C=C/c2c(cc(cc2OC)OC)OC.[Na+] |
InChiKey | VLQLUZFVFXYXQE-USRGLUTNSA-M |
InChi | InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+; |
CAS Number | 1225497-78-8 |
MDL | MFCD11655911 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Formulation | light-yellow solid to off-white solid |
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Purity | 98% |
Storage | 3 years -20ºCpowder |
Solubility | 50mg/ml in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature |
HS Code |
Targets | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |