SABA1
SABA1 is an antibacterial agent against Pseudomonas aeruginosa and Escherichia coli. It functions by inhibiting biotin carboxylase (BC), an enzyme that catalyzes the first half-reaction of acetyl-CoA carboxylase (ACC), which is essential for fatty acid synthesis in bacteria. Notably, SABA1 exhibits an atypical inhibition mechanism by binding to the biotin binding site of BC in the presence of ADP. This unique mode of action positions SABA1 as a promising candidate in the development of new antibiotics, especially crucial in the face of rising antimicrobial resistance.
For research use only. We do not sell to patients.
Chemical Information
| Name | SABA1 |
|---|---|
| Iupac Chemical Name | ethyl 4-((2-chloro-5-(phenylcarbamoyl)phenyl)sulfonamido)benzoate |
| Synonyms | SABA1; SABA 1; SABA-1 |
| Molecular Formula | C22H19ClN2O5S |
| Molecular Weight | 458.91 |
| Smile | CCOC(C1=CC=C(C=C1)NS(=O)(C2=CC(C(NC3=CC=CC=C3)=O)=CC=C2Cl)=O)=O |
| InChiKey | LCDQWAPYDBBYCH-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H19ClN2O5S/c1-2-30-22(27)15-8-11-18(12-9-15)25-31(28,29)20-14-16(10-13-19(20)23)21(26)24-17-6-4-3-5-7-17/h3-14,25H,2H2,1H3,(H,24,26) |
| CAS Number | 690681-65-3 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Craft MK, Waldrop GL. Mechanism of biotin carboxylase inhibition by ethyl
4-[[2-chloro-5-(phenylcarbamoyl)phenyl]sulphonylamino]benzoate. J Enzyme Inhib
Med Chem. 2022 Dec;37(1):100-108. doi: 10.1080/14756366.2021.1994558. PMID:
34894987; PMCID: PMC8667948.
2: Kloser A, Laird M, Deng M, Misra R. Modulations in lipid A and phospholipid
biosynthesis pathways influence outer membrane protein assembly in Escherichia
coli K-12. Mol Microbiol. 1998 Mar;27(5):1003-8. doi:
10.1046/j.1365-2958.1998.00746.x. PMID: 9535089.
3: Li Z, Huang L, Chen X, Liu Q, Liu Y, Liu C, Yu C, Feng Y. Contribution of
plant growth-promoting endophytic bacteria from hyperaccumulator to non-host
plant zinc nutrition and health. Int J Phytoremediation. 2025;27(1):23-35. doi:
10.1080/15226514.2024.2395983. Epub 2024 Aug 26. PMID: 39185733.
Chemical Structure
