<span style="color:#34495E;font-family:" font-size:14px;background-color:#ffffff;">SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells.
For research use only. We do not sell to patients.
Name | SAR-405 |
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Iupac Chemical Name | (S)-9-((5-chloropyridin-3-yl)methyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one |
Synonyms | SAR-405;SAR 405;SAR405 |
Molecular Formula | C19H21ClF3N5O2 |
Molecular Weight | 443.8552 |
Smile | ClC=1C=C(C=NC1)CN1[C@@H](CCN2C1=NC(=CC2=O)N2[C@@H](COCC2)C)C(F)(F)F |
InChiKey | SPDQRCUBFSRAFI-DOMZBBRYSA-N |
InChi | InChI=1S/C19H21ClF3N5O2/c1-12-11-30-5-4-26(12)16-7-17(29)27-3-2-15(19(21,22)23)28(18(27)25-16)10-13-6-14(20)9-24-8-13/h6-9,12,15H,2-5,10-11H2,1H3/t12-,15+/m1/s1 |
CAS Number | 1523406-39-4 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | off-white solid |
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Purity | 98.0% |
Storage | -20 ºC for 3 years |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature |
HS Code |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |