SB-505124 is a selective inhibitor of TGFR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.
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Chemical Information
Name SB-505124
Iupac Chemical Name 2-[4-(1,3-benzodioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl]-6-methylpyridine
Synonyms SB 505124; SB505124
Molecular Formula C20H21N3O2
Molecular Weight 335.40
Smile CC1=CC=CC(C2=C(C3=CC=C(OCO4)C4=C3)N=C(C(C)(C)C)N2)=N1
InChiKey WGZOTBUYUFBEPZ-UHFFFAOYSA-N
InChi InChI=1S/C20H21N3O2/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15/h5-10H,11H2,1-4H3,(H,22,23)
CAS Number 694433-59-5
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Ordering Information
Packaging Price Availability Purity Shipping Time
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Formulation Solid powder
Purity 98%
Storage -20 ºC for 3 years
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study