SBI0206965
Catalog No: 71161
CAS Number: 1884220-36-3
Purity: 98%
SBI0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor. Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergized with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells, providing a strong rationale for their combined use in the clinic.
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Chemical Information
| Name | SBI0206965 |
|---|---|
| Iupac Chemical Name | 2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide |
| Synonyms | SBI-0206965; SBI 0206965; SBI0206965 |
| Molecular Formula | C21H21BrN4O5 |
| Molecular Weight | 489.33 |
| Smile | BrC=1C(=NC(=NC1)NC1=CC(=C(C(=C1)OC)OC)OC)OC1=C(C(=O)NC)C=CC=C1 |
| InChiKey | NEXGBSJERNQRSV-UHFFFAOYSA-N |
| InChi | InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26) |
| CAS Number | 1884220-36-3 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid to white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | 10 mM in DMSO; |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
