SB 525334 is a potent and selective inhibitor of TGF_beta_ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.
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Chemical Information
Name SB 525334
Iupac Chemical Name 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline
Synonyms SB-525334; SB525334
Molecular Formula C21H21N5
Molecular Weight 343.42
Smile C(C)(C)(C)C=1NC(=C(N1)C=1C=C2N=CC=NC2=CC1)C1=NC(=CC=C1)C
InChiKey DKPQHFZUICCZHF-UHFFFAOYSA-N
InChi InChI=1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
CAS Number 356559-20-1
Related CAS
Ordering Information
Packaging Price Availability Purity Shipping Time
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Formulation Solid powder
Purity 98%
Storage -20 ºC for 3 years
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study