SIS3
Catalog No: 16122721
CAS Number: 521984-48-5
Purity: 98%
SIS3, a novel specific inhibitor of Smad3, inhibits TGF- and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways. SIS3 also inhibits the myofibroblast differentiation of fibroblasts by TGF-1. SIS3 completely diminishes the constitutive phosphorylation of Smad3 as well as the up-regulated type I collagen expression in scleroderma fibroblasts, thus abolishes the ECM overexpression in the TGF-1-treated normal dermal fibroblasts and scleroderma fibroblasts in vitro
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Chemical Information
| Name | SIS3 |
|---|---|
| Iupac Chemical Name | SIS3 |
| Synonyms | N/A |
| Molecular Formula | C28H27N3O3.HCl |
| Molecular Weight | 489.99 |
| Smile | Cn1c(c(c2c1nccc2)/C=C/C(=O)N3CCc4cc(c(cc4C3)OC)OC)c5ccccc5.Cl |
| InChiKey | CDKIEBFIMCSCBB-CALJPSDSSA-N |
| InChi | InChI=1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+; |
| CAS Number | 521984-48-5 |
| MDL | MFCD09265258 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
