SJB3-019A is a potent and novel usp1 inhibitor. SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.
SJB3-019A also increased the levels of Ub-FANCD2 and Ub-PCNA, and decreased the HR activity .
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Name | SJB3-019A |
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Iupac Chemical Name | SJB3-019A |
Molecular Formula | C16H8N2O3 |
Molecular Weight | 276.25 |
Smile | C[Si](C)(C)CSCCl |
InChiKey | IKWIERSJEROYFH-UHFFFAOYSA-N |
InChi | InChI=1S/C5H13ClSSi/c1-8(2,3)5-7-4-6/h4-5H2,1-3H3 |
CAS Number | 2070015-29-9 |
MDL | MFCD17013410 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | crystalline solid |
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Purity | 98% |
Storage | 3 years -20ºCpowder |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
HS Code |
Targets | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |