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SKF-91488 HCl

Catalog No: 20662
CAS Number: 68941-21-9
Purity: 98% Min.

SKF 91488 dihydrochloride is a homolog of dimaprit.

For research use only. We do not sell to patients.

Chemical Information

NameSKF-91488 HCl
Iupac Chemical Name4-(dimethylamino)butyl carbamimidothioate dihydrochloride
SynonymsSKF 91488 dihydrochloride; SKF 91488 HCl; SKF91488 HCl; SKF 91488 dihydrochloride
Molecular FormulaC7H19Cl2N3S
Molecular Weight248.22
SmileCN(CCCCSC(=N)N)C.Cl.Cl
InChiKeyNPLHSMBWWIIWAQ-UHFFFAOYSA-N
InChiInChI=1S/C7H17N3S.2ClH/c1-10(2)5-3-4-6-11-7(8)9;;/h3-6H2,1-2H3,(H3,8,9);2*1H
CAS Number68941-21-9
Related CAS

Ordering Information

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FormulationSolid powder
Purity98% Min.
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Jochem J, Zwirska-Korczala K, Rybus-Kalinowska B, Jagodzińska J, Korzonek-
Szlacheta I. Influence of SKF 91488, histamine N-methyltransferase inhibitor, on
the central cardiovascular regulation during controlled, stepwise hemorrhagic
hypotension in rats. Pol J Pharmacol. 2002 May-Jun;54(3):237-44. PMID: 12398155.

2: Malmberg-Aiello P, Lamberti C, Ipponi A, Hänninen J, Ghelardini C, Bartolini
A. Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301
U, in rodent antinociception. Naunyn Schmiedebergs Arch Pharmacol. 1997
Mar;355(3):354-60. doi: 10.1007/pl00004954. PMID: 9089666.

3: Jochem J. Endogenous central histamine-induced reversal of critical
haemorrhagic hypotension in rats--studies with histamine N-methyltransferase
inhibitor SKF 91488. Inflamm Res. 2002 Nov;51(11):551-6. doi:
10.1007/pl00012426. PMID: 12540019.

4: Klein MC, Gertner SB. Evidence for a role of endogenous histamine in central
cardiovascular regulation: inhibition of histamine-N-methyltransferase by SKF
91488. J Pharmacol Exp Ther. 1981 Feb;216(2):315-20. PMID: 6450831.

5: Nakazawa H, Sekizawa K, Morikawa M, Yamauchi K, Satoh M, Maeyama K, Watanabe
T, Sasaki H. Viral respiratory infection causes airway hyperresponsiveness and
decreases histamine N-methyltransferase activity in guinea pigs. Am J Respir
Crit Care Med. 1994 May;149(5):1180-5. doi: 10.1164/ajrccm.149.5.8173757. PMID:
8173757.

Chemical Structure

20662 - SKF-91488 HCl | CAS 68941-21-9

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