SX-682
Catalog No: 24082
CAS Number: 1648843-04-2
Purity: 98% Min.
SX-682 is a potent and selective Cxcr1/2 inhibitor potentially useful for castration-resistant prostate cancer. CXCR1 and CXCR2 chemokine receptors and their ligands (CXCL1/2/3/7/8) play an important role in tumor progression.
For research use only. We do not sell to patients.
Chemical Information
| Name | SX-682 |
|---|---|
| Iupac Chemical Name | (2-(((5-((4-fluorophenyl)carbamoyl)pyrimidin-2-yl)thio)methyl)-4-(trifluoromethoxy)phenyl)boronic acid |
| Synonyms | SX-682; SX 682; SX682. |
| Molecular Formula | C19H14BF4N3O4S |
| Molecular Weight | 467.20 |
| Smile | O=C(C1=CN=C(SCC2=CC(OC(F)(F)F)=CC=C2B(O)O)N=C1)NC3=CC=C(F)C=C3 |
| InChiKey | SDUDZBCEHIZMFZ-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H14BF4N3O4S/c21-13-1-3-14(4-2-13)27-17(28)12-8-25-18(26-9-12)32-10-11-7-15(31-19(22,23)24)5-6-16(11)20(29)30/h1-9,29-30H,10H2,(H,27,28) |
| CAS Number | 1648843-04-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Lu X, Horner JW, Paul E, Shang X, Troncoso P, Deng P, Jiang S, Chang Q, Spring
DJ, Sharma P, Zebala JA, Maeda DY, Wang YA, DePinho RA. Effective combinatorial
immunotherapy for castration-resistant prostate cancer. Nature. 2017 Mar 20. doi:
10.1038/nature21676. [Epub ahead of print] PubMed PMID: 28321130.
Chemical Structure
