Selonsertib is a apoptosis signal-regulating kinase inhibitor (ASK1). Selonsertib may be potential useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases.
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Chemical Information
Name Selonsertib(GS-4997)
Iupac Chemical Name 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide
Synonyms GS-4997; GS4997; GS 4997; Selonsertib free base
Molecular Formula C24H24FN7O
Molecular Weight 445.49
Smile O=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F
InChiKey YIDDLAAKOYYGJG-UHFFFAOYSA-N
InChi InChI=1S/C24H24FN7O/c1-14(2)32-13-27-30-23(32)19-5-4-6-22(28-19)29-24(33)17-10-21(15(3)9-18(17)25)31-11-20(26-12-31)16-7-8-16/h4-6,9-14,16H,7-8H2,1-3H3,(H,28,29,33)
CAS Number 1448428-04-3
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Ordering Information
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Formulation off-white solid to white solid
Purity 98% by HPLC/HNMR
Storage 3 years -20ºCpowder 6 months-80ºCin solvent
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study