Semaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 M, 20-fold more selective for VEGFR than PDGFR, lack of activity against EGFR, InsR and FGFR. Phase 3.
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Name | Semaxanib (SU5416) |
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Iupac Chemical Name | 2H-Indol-2-one,3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-, (3Z)- |
Synonyms | Semaxanib;SU5416 |
Molecular Formula | C15H14N2O |
Molecular Weight | 238.28 |
Smile | Cc1cc([nH]c1/C=C\2/c3ccccc3NC2=O)C |
InChiKey | WUWDLXZGHZSWQZ-WQLSENKSSA-N |
InChi | InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8- |
CAS Number | 204005-46-9 |
MDL | MFCD09763655 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Formulation | yellow solid |
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Purity | 98% |
Storage | 3 years -20ºCpowder |
Solubility | 5mg/ml in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature |
HS Code |
Targets | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |