Sulfatinib is an orally bioavailable, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, and the fibroblast growth factor receptor type 1 (FGFR1).
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Chemical Information
Name Sulfatinib
Iupac Chemical Name N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide
Synonyms HMPL012; HMPL012; HMPL 012; Sulfatinib
Molecular Formula C24H28N6O3S
Molecular Weight 480.587
Smile CN(CCNS(=O)(=O)CC1=CC(=CC=C1)NC1=NC=CC(=N1)OC=1C=C2C=C(NC2=CC1)C)C
InChiKey TTZSNFLLYPYKIL-UHFFFAOYSA-N
InChi InChI=1S/C24H28N6O3S/c1-17-13-19-15-21(7-8-22(19)27-17)33-23-9-10-25-24(29-23)28-20-6-4-5-18(14-20)16-34(31,32)26-11-12-30(2)3/h4-10,13-15,26-27H,11-12,16H2,1-3H3,(H,25,28,29)
CAS Number 1308672-74-3
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Ordering Information
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Formulation off-white solid
Purity 98.0%
Storage -20 ℃ for 3 years
Solubility Soluble in DMSO
Handling
Shipping Condition Shipped under ambient temperature
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study