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TAK-653

Catalog No: 25070
CAS Number: 1358751-06-0
Purity: 98% Min.

 TAK-653 is a novel AMPA receptor potentiator, strictly potentiating a glutamate-induced Ca2+ influx in hGluA1i-expressing CHO cells through structural interference at Ser743 in GluA1,

For research use only. We do not sell to patients.

Chemical Information

NameTAK-653
Iupac Chemical Name9-(4-(cyclohexyloxy)phenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide
SynonymsTAK-653; TAK653; TAK 653; NBI-1065845; NBI1065845; NBI 1065845; osavampator
Molecular FormulaC19H23N3O3S
Molecular Weight373.47
SmileCC1=CN(CC2)C(C(C3=CC=C(OC4CCCCC4)C=C3)=N1)=NS2(=O)=O
InChiKeyPXJBHEHFVQVDDS-UHFFFAOYSA-N
InChiInChI=1S/C19H23N3O3S/c1-14-13-22-11-12-26(23,24)21-19(22)18(20-14)15-7-9-17(10-8-15)25-16-5-3-2-4-6-16/h7-10,13,16H,2-6,11-12H2,1H3
CAS Number1358751-06-0
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Ordering Information

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FormulationOff-white solid
Purity98% Min.
StorageDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Witkin JM, Martin AE, Golani LK, Xu NZ, Smith JL. Rapid-acting antidepressants. Adv Pharmacol. 2019;86:47-96. doi: 10.1016/bs.apha.2019.03.002. Epub 2019 Apr 24. PMID: 31378256.


2: O'Donnell P, Dijkstra FM, Damar U, Quanhong L, de Goede AA, Xu L, Pascual- Leone A, Buhl DL, Zuiker R, Ruijs TQ, Heuberger JAAC, MacMullin P, Lubell M, Asgharnejad M, Murthy V, Rotenberg A, Jacobs GE, Rosen L. Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation. Transl Psychiatry. 2021 May 27;11(1):325. doi: 10.1038/s41398-021-01451-2. PMID: 34045439; PMCID: PMC8160137.


3: Suzuki A, Kunugi A, Tajima Y, Suzuki N, Suzuki M, Toyofuku M, Kuno H, Sogabe S, Kosugi Y, Awasaki Y, Kaku T, Kimura H. Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement. Sci Rep. 2021 Jul 15;11(1):14532. doi: 10.1038/s41598-021-93888-0. Erratum in: Sci Rep. 2021 Jul 21;11(1):15255. doi: 10.1038/s41598-021-94772-7. PMID: 34267258; PMCID: PMC8282797.


4: Suzuki A, Kunugi A, Tajima Y, Suzuki N, Suzuki M, Toyofuku M, Kuno H, Sogabe S, Kosugi Y, Awasaki Y, Kaku T, Kimura H. Author Correction: Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement. Sci Rep. 2021 Jul 21;11(1):15255. doi: 10.1038/s41598-021-94772-7. Erratum for: Sci Rep. 2021 Jul 15;11(1):14532. doi: 10.1038/s41598-021-93888-0. PMID: 34290388; PMCID: PMC8295271.


5: Hara H, Suzuki A, Kunugi A, Tajima Y, Yamada R, Kimura H. TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats. Pharmacol Biochem Behav. 2021 Dec;211:173289. doi: 10.1016/j.pbb.2021.173289. Epub 2021 Oct 14. PMID: 34655652.


6: Dijkstra F, O'Donnell P, Klaassen E, Buhl D, Asgharnejad M, Rosen L, Zuiker R, van Gerven J, Jacobs G. Central nervous system effects of TAK-653, an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole receptor (AMPAR) positive allosteric modulator in healthy volunteers. Transl Psychiatry. 2022 Sep 24;12(1):408. doi: 10.1038/s41398-022-02148-w. PMID: 36153330; PMCID: PMC9509332.


7: Suzuki A, Hara H, Kimura H. Role of the AMPA receptor in antidepressant effects of ketamine and potential of AMPA receptor potentiators as a novel antidepressant. Neuropharmacology. 2023 Jan 1;222:109308. doi: 10.1016/j.neuropharm.2022.109308. Epub 2022 Oct 29. PMID: 36341809.


8: Lin S, Ionescu A, Maynard-Scott J, Kennedy M, Walling DP, Furey M, Singh JB. Effects of the selective AMPA modulator NBI-1065845 on the pharmacokinetics of midazolam or ethinyl estradiol-levonorgestrel in healthy adults. Clin Transl Sci. 2024 May;17(5):e13791. doi: 10.1111/cts.13791. PMID: 38700236; PMCID: PMC11067504.


9: Osaka H, Kanazawa T. Emerging trends in antipsychotic and antidepressant drug development: Targeting nonmonoamine receptors and innovative mechanisms. PCN Rep. 2023 Nov 20;2(4):e157. doi: 10.1002/pcn5.157. PMID: 38868733; PMCID: PMC11114387.

Chemical Structure

25070 - TAK-653 | CAS 1358751-06-0

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