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TAK-779

Catalog No: 25049
CAS Number: 229005-80-5
Purity: 98% Min.

TAK-779 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist potentially for the treatment of HIV infection. Treatment with TAK-779 reduced incidence and severity of experimental autoimmune encephalomyelitis. It strongly inhibited migration of CXCR3/CCR5 bearing CD4+, CD8+ and CD11b+ leukocytes to the CNS. TAK-779 did not reduce proliferation of anti-myelin oligodendrocyte glycoprotein T cells, the production of IFN-gamma by T cells or CXCR3 expression on T cells. In addition, TAK-779 did not affect production of IL-12 by antigen-presenting cells, CCR5 induction on T cells and the potential of myelin oligodendrocyte glycoprotein-specific T cells to transfer experimental autoimmune encephalomyelitis.

For research use only. We do not sell to patients.

Chemical Information

NameTAK-779
Iupac Chemical NameN,N-dimethyl-N-(4-(2-(p-tolyl)-6,7-dihydro-5H-benzo[7]annulene-8-carboxamido)benzyl)tetrahydro-2H-pyran-4-aminium chloride
SynonymsTAK-779, TAK 779, TAK779 Chloride;
Molecular FormulaC33H39ClN2O2
Molecular Weight531.13
SmileC[N+](C)(CC1=CC=C(NC(C2=CC3=CC(C4=CC=C(C)C=C4)=CC=C3CCC2)=O)C=C1)C5CCOCC5.[Cl-]
InChiKeyVDALIBWXVQVFGZ-UHFFFAOYSA-N
InChiInChI=1S/C33H38N2O2.ClH/c1-24-7-11-27(12-8-24)28-14-13-26-5-4-6-29(22-30(26)21-28)33(36)34-31-15-9-25(10-16-31)23-35(2,3)32-17-19-37-20-18-32;/h7-16,21-22,32H,4-6,17-20,23H2,1-3H3;1H
CAS Number229005-80-5
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Ordering Information

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FormulationOff-white solid
Purity98% Min.
StorageDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

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9: Spenlehauer C, Gordon CA, Trkola A, Moore JP. A luciferase-reporter gene- expressing T-cell line facilitates neutralization and drug-sensitivity assays that use either R5 or X4 strains of human immunodeficiency virus type 1. Virology. 2001 Feb 15;280(2):292-300. doi: 10.1006/viro.2000.0780. PMID: 11162843.


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17920529.

Chemical Structure

25049 - TAK-779 | CAS 229005-80-5

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