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TCRS-417

Catalog No: 24141
CAS Number: 2032123-28-5
Purity: 98% Min.

TCRS-417 (T417) is a small molecule compound capable of docking to the interface between PBX1 and its cognate DNA target sequence, effectively interfering with PBX1-DNA interaction.

For research use only. We do not sell to patients.

Chemical Information

NameTCRS-417
Iupac Chemical NameN-(4-(2-((3,4-dihydroxyphenyl)amino)-2-oxoethoxy)naphthalen-1-yl)-3-fluorobenzamide
SynonymsTCRS-417; TCRS417; TCRS 417; T417; T-417; T 417
Molecular FormulaC25H19FN2O5
Molecular Weight446.43
SmileO=C(C1=CC(F)=CC=C1)NC2=CC=C(C3=C2C=CC=C3)OCC(NC4=CC=C(C(O)=C4)O)=O
InChiKeyFAUNPVFPOMPBQA-UHFFFAOYSA-N
InChiInChI=1S/C25H19FN2O5/c26-16-5-3-4-15(12-16)25(32)28-20-9-11-23(19-7-2-1-6-18(19)20)33-14-24(31)27-17-8-10-21(29)22(30)13-17/h1-13,29-30H,14H2,(H,27,31)(H,28,32)
CAS Number2032123-28-5
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Ordering Information

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FormulationOff-white solid
Purity98% Min.
StorageDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

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multiple neurodegenerative diseases. PLoS One. 2010 Feb 2;5(2):e9002. doi:
10.1371/journal.pone.0009002. PMID: 20126313; PMCID: PMC2814869.

9: Palmbos PL, Wu D, Daley JM, Wilson TE. Recruitment of Saccharomyces
cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with
Yku80 and the Xrs2 FHA domain. Genetics. 2008 Dec;180(4):1809-19. doi:
10.1534/genetics.108.095539. Epub 2008 Oct 1. PMID: 18832348; PMCID: PMC2600923.

10: Xie W, Wang SA, Yin CC, Xu J, Li S, Bueso-Ramos CE, Medeiros LJ, Tang G.
Acute myeloid leukemia with t(8;21)(q22;q22.1)/RUNX1-RUNX1T1 and KIT Exon 8
mutation is associated with characteristic mastocytosis and dismal outcomes. Exp
Mol Pathol. 2019 Jun;108:131-136. doi: 10.1016/j.yexmp.2019.04.009. Epub 2019
Apr 17. PMID: 31004601.

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subdomain IA is a mediator of interdomain allostery in Hsp70 molecular
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AH, Bieńkowska-Szewczyk K, Grzyb K. Effect of Glycan Shift on Antibodies against
Hepatitis C Virus E2 412-425 Epitope Elicited by Chimeric sHBsAg-Based Virus-
Like Particles. Microbiol Spectr. 2023 Jan 31;11(2):e0254622. doi:
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PMC10100762.

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PMID: 23114923; PMCID: PMC4487418.

Chemical Structure

24141 - TCRS-417 | CAS 2032123-28-5

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