TDZD-8
Catalog No: 161009029
CAS Number: 327036-89-5
Purity: 98% by HPLC
TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity. TDZD-8 decreased proliferation and induced apoptosis of GL261 glioblastoma cells in vitro, delayed tumor growth in vivo, and augmented animal survival. These effects were associated with an early activation of extracellular signal-regulated kinase (ERK) pathway and increased expression of EGR-1 and p21 genes. Treatment of glioblastoma stem cells with TDZD-8 resulted in an inhibition of proliferation and self-renewal of these cells.
For research use only. We do not sell to patients.
Chemical Information
| Name | TDZD-8 |
|---|---|
| Iupac Chemical Name | 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione |
| Synonyms | TDZD8; TDZD-8; TDZD 8. GSK3 Inhibitor I; NP 01139. |
| Molecular Formula | C10H10N2O2S |
| Molecular Weight | 222.26 |
| Smile | C(C1=CC=CC=C1)N1C(N(SC1=O)C)=O |
| InChiKey | JDSJDASOXWCHPN-UHFFFAOYSA-N |
| InChi | InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3 |
| CAS Number | 327036-89-5 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
