TGN 073
TGN 073 is a facilitator of aquaporin-4 (AQP4), an astroglial water channel. The rats treated with TGN-073 showed the distribution of Gd-DTPA was more extensive and parenchymal uptake was higher compared with the vehicle group. Water diffusivity was increased in the brain of TGN-073 treated group, which indicates greater water flux. Also, MRI showed the glymphatic transport and distribution in the brain is naturally heterogeneous. TGN-073 can improve glymphatic function in the brain。
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Chemical Information
| Name | TGN 073 |
|---|---|
| Iupac Chemical Name | N-(3-(benzyloxy)pyridin-2-yl)benzenesulfonamide |
| Synonyms | TGN 073; TGN073; TGN-073 |
| Molecular Formula | C18H16N2O3S |
| Molecular Weight | 340.40 |
| Smile | O=S(NC1=NC=CC=C1OCC2=CC=CC=C2)(C3=CC=CC=C3)=O |
| InChiKey | JBHHMMLJGNLVNB-UHFFFAOYSA-N |
| InChi | InChI=1S/C18H16N2O3S/c21-24(22,16-10-5-2-6-11-16)20-18-17(12-7-13-19-18)23-14-15-8-3-1-4-9-15/h1-13H,14H2,(H,19,20) |
| CAS Number | 877459-36-4 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Alghanimy A, Martin C, Gallagher L, Holmes WM. The effect of a novel AQP4
facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-
MRI. PLoS One. 2023 Mar 15;18(3):e0282955. doi: 10.1371/journal.pone.0282955.
PMID: 36920936; PMCID: PMC10016657.
2: Huber VJ, Igarashi H, Ueki S, Kwee IL, Nakada T. Aquaporin-4 facilitator
TGN-073 promotes interstitial fluid circulation within the blood-brain barrier:
[17O]H2O JJVCPE MRI study. Neuroreport. 2018 Jun 13;29(9):697-703. doi:
10.1097/WNR.0000000000000990. PMID: 29481527; PMCID: PMC5965936.
3: Peng W, Yuan Y, Lei J, Zhao Y, Li Y, Qu Q, Wang J. Long-Term High-Fat Diet
Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta. Mol Neurobiol. 2024
Jul 3. doi: 10.1007/s12035-024-04320-3. Epub ahead of print. PMID: 38958889.
Chemical Structure
