TH-302
Catalog No: 011812
CAS Number: 918633-87-1
Purity: 98%
TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.
For research use only. We do not sell to patients.
Chemical Information
| Name | TH-302 |
|---|---|
| Iupac Chemical Name | 2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine |
| Synonyms | TH302; TH 302; Evofosfamide |
| Molecular Formula | C9H16Br2N5O4P |
| Molecular Weight | 449.036 |
| Smile | CN1C(=CN=C1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr |
| InChiKey | UGJWRPJDTDGERK-UHFFFAOYSA-N |
| InChi | InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/h6H,2-5,7H2,1H3,(H2,13,14,19) |
| CAS Number | 918633-87-1 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
