TRPM4-IN-2
TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM.
For research use only. We do not sell to patients.
Chemical Information
| Name | TRPM4-IN-2 |
|---|---|
| Iupac Chemical Name | 4-chloro-2-(2-(naphthalen-1-yloxy)acetamido)benzoic acid |
| Synonyms | TRPM4-IN-2; TRPM4 IN-2; TRPM4-IN 2; NBA |
| Molecular Formula | C19H14ClNO4 |
| Molecular Weight | 355.77 |
| Smile | O=C(O)C1=CC=C(Cl)C=C1NC(COC2=C3C=CC=CC3=CC=C2)=O |
| InChiKey | OKFVCWAYHJMQFA-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H14ClNO4/c20-13-8-9-15(19(23)24)16(10-13)21-18(22)11-25-17-7-3-5-12-4-1-2-6-14(12)17/h1-10H,11H2,(H,21,22)(H,23,24) |
| CAS Number | 667411-04-3 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1. Borgström A, Hauert B, Kappel S, Zoni E, Kiener M, Stokłosa P, Baur R, Spahn M, Kruithof-de Julio M, Peinelt C. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665. doi: 10.1016/j.jmb.2020.09.024. Epub 2020 Oct 12. PMID: 33058873.
2. Stokłosa P, Borgström A, Hauert B, Baur R, Peinelt C. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel). 2021 Oct 28;13(21):5400. doi: 10.3390/cancers13215400. PMID: 34771564; PMCID: PMC8582472.
Chemical Structure
