Tirabrutinib free base ( ONO-4059 )
Catalog No: 17031303
CAS Number: 1351636-18-4
Purity: ≧98.0%
Tirabrutinib, also known as ONO-4059 is a potent and orally active Bruton agammaglobulinemia tyrosine kinase (BTK) inhibitor. Upon administration, ONO-4059 covalently binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.
For research use only. We do not sell to patients.
Chemical Information
| Name | Tirabrutinib free base ( ONO-4059 ) |
|---|---|
| Iupac Chemical Name | (R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one |
| Synonyms | ONO-4059 ; ONO4059 ; ONO 4059 ; ONO-4059 ; GS 4059 ; GS-4059 ; GS4059 ; ONO-WG-307 ; Tirabrutinib |
| Molecular Formula | C25H22N6O3 |
| Molecular Weight | 454.49 |
| Smile | NC1=C2N(C(N(C2=NC=N1)[C@H]1CN(CC1)C(C#CC)=O)=O)C1=CC=C(C=C1)OC1=CC=CC=C1 |
| InChiKey | SEJLPXCPMNSRAM-GOSISDBHSA-N |
| InChi | InChI=1S/C25H22N6O3/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28)/t18-/m1/s1 |
| CAS Number | 1351636-18-4 |
| Related CAS | 1351636-18-4 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | BTK inhibitor |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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