Trametinib (GSK1120212)
Catalog No: 52109
CAS Number: 871700-17-3
Purity: 98%
Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.
For research use only. We do not sell to patients.
Chemical Information
| Name | Trametinib (GSK1120212) |
|---|---|
| Iupac Chemical Name | N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide |
| Synonyms | Trametinib,GSK1120212 |
| Molecular Formula | C26H23FIN5O4 |
| Molecular Weight | 615.39 |
| Smile | C1(CC1)N1C(N(C=2C(C1=O)=C(N(C(C2C)=O)C)NC2=C(C=C(C=C2)I)F)C=2C=C(C=CC2)NC(C)=O)=O |
| InChiKey | LIRYPHYGHXZJBZ-UHFFFAOYSA-N |
| InChi | InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34) |
| CAS Number | 871700-17-3 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder 6 months-80ºCin solvent |
| Solubility | 5mg/ml in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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