Trilaciclib (G1T28)
Catalog No: 185235
CAS Number: 1374743-00-6
Purity: >98%
TRILACICLIB (G1T28), A HIGHLY POTENT, TRANSIENT CDK 4/6 INHIBITOR WITH IC50s OF 1 nM AND 4 nM FOR CDK4 AND CDK6, RESPECTIVELY, HAS THE POTENTIAL TO DECREASE MYELOTOXICITY AND IMPROVE ANTI-TUMOR EFFICACY.
TRILACICLIB (G1T28), Bulk in stock, contact us by email for the Bulk quotation.
For research use only. We do not sell to patients.
Chemical Information
| Name | Trilaciclib (G1T28) |
|---|---|
| Iupac Chemical Name | 2'-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one |
| Synonyms | G1T28 ; G1T-28 ; G1T 28 ; Trilaciclib. |
| Molecular Formula | C24H30N8O |
| Molecular Weight | 446.559 |
| Smile | O=C1NCC2(N3C1=CC4=CN=C(NC5=NC=C(N6CCN(C)CC6)C=C5)N=C43)CCCCC2 |
| InChiKey | PDGKHKMBHVFCMG-UHFFFAOYSA-N |
| InChi | InChI=1S/C24H30N8O/c1-30-9-11-31(12-10-30)18-5-6-20(25-15-18)28-23-26-14-17-13-19-22(33)27-16-24(7-3-2-4-8-24)32(19)21(17)29-23/h5-6,13-15H,2-4,7-12,16H2,1H3,(H,27,33)(H,25,26,28,29) |
| CAS Number | 1374743-00-6 |
| Related CAS | 1374743-00-6(Free base) ; 1977495-97-8 (2HCl) |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid to white solid |
|---|---|
| Purity | >98% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| Shipping Condition | Shipped under ambient temperature |
| HS Code | 2933999701 |
| Targets | intravenous CDK4/6 inhibitor |
|---|---|
| Mechanism | TRILACICLIB (G1T28), A HIGHLY POTENT, TRANSIENT CDK 4/6 INHIBITOR WITH IC50s OF 1 nM AND 4 nM FOR CDK4 AND CDK6, RESPECTIVELY, HAS THE POTENTIAL TO DECREASE MYELOTOXICITY AND IMPROVE ANTI-TUMOR EFFICACY. |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
