UNC5293
Catalog No: 24094
CAS Number: 2226789-82-6
Purity: 98% Min.
UNC5293 is a MERTK -selective and potent inhibitor ( Ki=190 pM).
For research use only. We do not sell to patients.
Chemical Information
| Name | UNC5293 |
|---|---|
| Iupac Chemical Name | (2,6-dimethylpyridin-4-yl)(4-(7-(4-hydroxycyclohexyl)-2-(pentan-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)piperidin-1-yl)methanone |
| Synonyms | UNC5293; UNC 5293; UNC-5293 |
| Molecular Formula | C30H42N6O2 |
| Molecular Weight | 518.69 |
| Smile | CCCC(C)NC1=NC=C2C(=CN(C2=N1)C3CCC(CC3)O)C4CCN(CC4)C(=O)C5=CC(=NC(=C5)C)C |
| InChiKey | MSWOWUREQODTRO-UHFFFAOYSA-N |
| InChi | InChI=1S/C30H42N6O2/c1-5-6-19(2)33-30-31-17-26-27(18-36(28(26)34-30)24-7-9-25(37)10-8-24)22-11-13-35(14-12-22)29(38)23-15-20(3)32-21(4)16-23/h15-19,22,24-25,37H,5-14H2,1-4H3,(H,31,33,34) |
| CAS Number | 2226789-82-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Zheng H, Zhao J, Li B, Zhang W, Stashko MA, Minson KA, Huey MG, Zhou Y, Earp HS, Kireev D, Graham DK, DeRyckere D, Frye SV, Wang X. UNC5293, a potent, orally available and highly MERTK-selective inhibitor. Eur J Med Chem. 2021 Aug 5;220:113534. doi: 10.1016/j.ejmech.2021.113534. Epub 2021 May 17. PMID: 34038857.
Chemical Structure
