W-13 HCl
W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.
For research use only. We do not sell to patients.
Chemical Information
| Name | W-13 HCl |
|---|---|
| Iupac Chemical Name | N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide hydrochloride |
| Synonyms | W-13 HCl; W-13; W13; W 13; W-13 (hydrochloride) |
| Molecular Formula | C14H18Cl2N2O2S |
| Molecular Weight | 349.28 |
| Smile | ClC1=C2C(C=C(S(NCCCCN)(=O)=O)C=C2)=CC=C1.Cl |
| InChiKey | QKAALLVQBOLELJ-UHFFFAOYSA-N |
| InChi | InChI=1S/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H |
| CAS Number | 88519-57-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Wei JW, Hickie RA, Klaassen DJ. Inhibition of human breast cancer colony
formation by anticalmodulin agents: trifluoperazine, W-7, and W-13. Cancer
Chemother Pharmacol. 1983;11(2):86-90. doi: 10.1007/BF00254251. PMID: 6627600.
2: Sengupta P, Ruano MJ, Tebar F, Golebiewska U, Zaitseva I, Enrich C,
McLaughlin S, Villalobo A. Membrane-permeable calmodulin inhibitors (e.g.
W-7/W-13) bind to membranes, changing the electrostatic surface potential: dual
effect of W-13 on epidermal growth factor receptor activation. J Biol Chem. 2007
Mar 16;282(11):8474-86. doi: 10.1074/jbc.M607211200. Epub 2007 Jan 16. PMID:
17227773.
Chemical Structure
