Wu-5
Catalog No: 24160
CAS Number: 2630378-05-9
Purity: 98% Min.
Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis.
For research use only. We do not sell to patients.
Chemical Information
| Name | Wu-5 |
|---|---|
| Iupac Chemical Name | ethyl 5-(4-(methoxycarbonyl)phenoxy)-4-nitrothiophene-2-carboxylate |
| Synonyms | Wu-5; Wu5; Wu 5 |
| Molecular Formula | C15H13NO7S |
| Molecular Weight | 351.33 |
| Smile | O=C(C1=CC=C(C=C1)OC2=C([N+]([O-])=O)C=C(C(OCC)=O)S2)OC |
| InChiKey | ZOBORTAJZNJCLJ-UHFFFAOYSA-N |
| InChi | InChI=1S/C15H13NO7S/c1-3-22-14(18)12-8-11(16(19)20)15(24-12)23-10-6-4-9(5-7-10)13(17)21-2/h4-8H,3H2,1-2H3 |
| CAS Number | 2630378-05-9 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Yu M, Fang ZX, Wang WW, Zhang Y, Bu ZL, Liu M, Xiao XH, Zhang ZL, Zhang XM, Cao Y, Wang YY, Lei H, Xu HZ, Wu YZ, Liu W, Wu YL. Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta Pharmacol Sin. 2021 Apr;42(4):604-612. doi: 10.1038/s41401-020-0455-x. Epub 2020 Jul 21. PMID: 32694757; PMCID: PMC8115260.
Chemical Structure
