Y-39983 HCl
Catalog No: 17021305
CAS Number: 173897-44-4
Purity: 98%
Y-39983 is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM.
Y-39983 opposes ROCK-dependent phosphorylation of MYPT1 predominantly at Thr853 with a corresponding decrease in MLC phosphorylation. It reduces the phosphorylation at Thr696 and Thr853 and leads to reduced actomyosin contraction. Y-39983 shows an IC50 of ~200 nM for dephosphorylation at Thr696 and only 15 nM for dephosphorylation at Thr853. The IC50 for dephosphorylation of MLC is 14 nM
For research use only. We do not sell to patients.
Chemical Information
| Name | Y-39983 HCl |
|---|---|
| Iupac Chemical Name | Y-39983 HCl |
| Synonyms | Y-33075 HCl |
| Molecular Formula | C16H16N4O.2HCl |
| Molecular Weight | 353.25 |
| Smile | C[C@H](c1ccc(cc1)C(=O)Nc2ccnc3c2cc[nH]3)N.Cl.Cl |
| InChiKey | CKFHAVRPVZNMGT-YQFADDPSSA-N |
| InChi | InChI=1S/C16H16N4O.2ClH/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15;;/h2-10H,17H2,1H3,(H2,18,19,20,21);2*1H/t10-;;/m1../s1 |
| CAS Number | 173897-44-4 |
| MDL | MFCD00945328 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
