Y27632(free base)
Catalog No: 16070918
CAS Number: 146986-50-7
Purity: 98% by HPLC
Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats, increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium, affects initial heart myofibrillogenesis in cultured chick blastoderm, promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord.
For research use only. We do not sell to patients.
Chemical Information
| Name | Y27632(free base) |
|---|---|
| Iupac Chemical Name | (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide |
| Synonyms | Y27632; Y-27632 |
| Molecular Formula | C14H21N3O |
| Molecular Weight | 247.34 |
| Smile | C[C@H]([C@H]1CC[C@@H](CC1)C(=O)Nc2ccncc2)N |
| InChiKey | IYOZTVGMEWJPKR-IJLUTSLNSA-N |
| InChi | InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1 |
| CAS Number | 146986-50-7 |
| MDL | MFCD03093855 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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