ZL006
Catalog No: 16122851
CAS Number: 1181226-02-7
Purity: 98%
ZL006 is a PSD95-nNOS protein-protein interaction inhibitor. ZL006 (EC50: 12.88 M) directly inhibited binding of purified PSD95 and nNOS proteins in AlphaScreen without altering binding of PSD95 to ErbB4. ZL006 preferentially suppressed phase 2A pain behavior in the formalin test and suppressed allodynia induced by intraplantar complete Freund's adjuvant administration. Disrupting PSD95-nNOS protein-protein interactions is effective in attenuating pathological pain without producing unwanted side effects (i.e. motor ataxia) associated with NMDAR antagonists.
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Chemical Information
| Name | ZL006 |
|---|---|
| Iupac Chemical Name | ZL006 |
| Synonyms | ZL006; ZL-006; ZL 006 |
| Molecular Formula | C14H11Cl2NO4 |
| Molecular Weight | 328.145 |
| Smile | c1cc(c(cc1NCc2cc(cc(c2O)Cl)Cl)O)C(=O)O |
| InChiKey | RTEYSQSXRFVKTJ-UHFFFAOYSA-N |
| InChi | InChI=1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21) |
| CAS Number | 1181226-02-7 |
| MDL | MFCD20527326 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
